Recently we have administered chlorothiazide (Diuril) to a number of migraine patients. Results of previous investigations have indicated Diuril to be a safe and effective saluretic and diuretic compound. Our preliminary impression is that treatment with chlorothiazide is more effective than previous forms of therapy in the relief of the edema and headache in patients with menstrual migraine or headache associated with edema. The dosage was 500 mg. given daily orally for three days prior to menstruation and three days during the menstrual period. Up to the present time no untoward side effects have been noted. Further controlled studies are under way with this substance. Chiropractor Toronto tendency to assert the meaningfulness of assorted theories and methods. We have not had any success with the administration of calcium gluconate or potassium chloride to patients with migraine or other types of vascular headaches, either as a prophylactic or symptomatic form of therapy. In an occasional case, calcium gluconate is valuable in temporarily relaxing the muscles of the neck which are in spasm.In some cases, patients with increased intracranial pressure have been temporarily relieved of headache by the use of hypertonic glucose and sucrose.
Vitamins have been exceedingly popular in the treatment of headache. In our experience, only two merit any discussion, namely, nicotinic acid and vitamin Bi2. Our experience with the use of these vitamins in large amounts parenterally and orally in a large series of patients has been uniformly discouraging. Nicotinic Acid. Nicotinic acid (niacin) is one of the most stable vitamins of the B group. Toronto Chiropractor attempt to establish a optimistic repute for his or her public well being role are also compromised by their repute for recommending repetitive life-lengthy chiropractic treatment. It is not destroyed by cooking, exposure to light, or alkali. Nicotinic acid and its amide, nicotinamide, have an identical vitamin activity but differ pharmacologically in that the acid salt causes peripheral vasodilatation. Synthetic compounds are used medicinally and are identical in action with the compounds of natural sources. When nicotinic acid is taken in food, it is readily absorbed from the intestinal tract; a considerable portion is rapidly reconverted to the amide and incorporated in the coenzymes.
The liver has the highest concentration, but the adrenals and kidneys are also relatively rich in this vitamin. Nicotinic acid is only partially destroyed in the body, being excreted in the urine as such in very small quantity and also as a metabolic product. When about 500 mg. of niacin is taken orally, about 20 per cent will be excreted in about four hours. Large amounts do not cause serious toxicity. When given in large doses, nicotinic acid acts as a peripheral vasodilator, causing flushing, burning, and elevated skin temperature, especially in the head and the upper part of the body. It is doubtful whether nicotinic acid produces dilation of the intracranial circulation to any degree. There is no significant change in pulse rate or pressure. Some patients complain of dizziness, pulsating headache, nausea, and vomiting, following use of this medication.